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Scientific studies of cannabdiol to date

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Cannabidiol: Therapeutic virtues at the heart of scientific research, for a better understanding of its mechanism.

Let us remind ourselves that CBD is a non-addictive and non-neutralizing molecule that is present in large quantities in Cannabis Sativa L.

What are its effects on our body? Numerous scientific studies try to answer.

A study conducted by neurobiology researchers in January 2019 demonstrates the effects of CBD on the serotonergic 5-HT receptor (5-hydroxytryptamine) in allydonies (pain to a stimulus that normally does not cause pain) and neuropathic pain. The 5-HT is located in the central and peripheral nervous system responsible for our good mood when its activity is in balance. In oral administration of CBD at different dosages (5,10, 20 and 40 mg/kg), improved neuropathic pain and attenuation of mechanical allodynia were observed. It should also be noted that there is a decrease in anxiety and an antidepressant effect with a minimum dose of 20 mg/kg. A panel of 1,045 patients with moderate intensity pain participated in a study published in October 2020 on the use of medical cannabis. After 12 months of treatment, 551 patients voluntarily continued the process. Post-treatment results showed a 20% decrease in pain, with a 95% confidence index. An improvement in sleep time, a body mass index (BMI) and a lower depression score should be noted.

How does CBD work on our body?

The anti-inflammatory, antinociceptive or antispasmodic effects of the cannabinoid could be explained by an interaction with several molecular targets involved in pain control. It has no direct affinity for the CB1 and CB2 receptors of the endocannabinoid system (biological regulation system) unlike the delta-9-tetrahydrocannabinol (THC), the psychoactive molecule of cannabis. Can it be used as a stress remedy? The therapeutic effect of CBD was the subject of a 2011 study by the American College of Neuropsychopharmacology that studied the effects of the molecule on generalized Social Anxiety Disorder (SAD). 24 DAS subjects and 12 Healthy Control (HC) subjects were divided into 2 groups to 8 receive one dose of CBD (SAD-CBD) and one placebo (SAD-PLAC). The SAD-PLAC group had a higher level of anxiety and cognitive impairment on the test. The result is not really surprising since the symptoms evoked are naturally present in people suffering from SAD.

Preliminary results emphasize that a dose of CBD can reduce the anxiety effect of public speaking. If you are suffering from refractory pain or pathologies involving heavy treatments with side effects, studies show an increased curiosity for the therapeutic benefits of the plant. Even if there is a clear fad nowadays, the clear infatuation for the molecule becomes increasingly justified by the results of promising scientific studies, which are only the beginnings of new natural solutions with very high potential for your health.

Pauline Bastide, Dietician/Nutritionist specializing in sports micronutrition

This article may interest you: "The painkillers abuse among athletes"

Glossary: Allodynia: pain triggered by a stimulus that is normally painless. Neuropathic pain: pain caused by damage to the nervous system. Nociceptive: capable of detecting pain.

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